2025

"Until now, little was known about how and when RNA does what it does inside cells. It turns out it’s been really quite difficult to know in living cells, and especially in living organisms, when RNA is turned on and where it goes. If you wanted to study the first 30 seconds or the first minute – nobody knows. But we provide a tool. You can now visualize it." (Andrej Luptak)

"By targeting key processes like RNA splicing and modification, we not only advance our understanding of the molecular disruptions behind HD but also open the door to potential new treatments for neurodegenerative diseases more broadly. It was a really important collaboration to bring chemical and genomic tools from my lab and merge them with Leslie’s powerful and robust model systems to nail down this novel mechanism." (Rob Spitale)