“Harnessing Stem Cell Derived Microglia for Brain-Wide Delivery of Therapeutic Proteins”
Mathew Blurton-Jones | UCI
Dr. Matt Blurton-Jones is a Professor in the Department of Neurobiology and Behavior at the University of California, Irvine and director of UCI’s ADRC iPSC core and Stem Cell CRISPR core. His current research uses human induced pluripotent stem cells (iPSCs), CRISPR engineering, and chimeric mouse models to examine the underlying molecular mechanisms that drive the development and progression of Alzheimer’s disease (AD). His group previously developed methods to differentiate patient-derived iPSCs into microglia and further combines this approach with xenotransplantation to study human microglial function in vivo. Most recently, his lab has begun using chimeric models of AD, frontotemporal dementia (FTD), and lysosomal storage disease to study the impact of disease risk genes on microglia biology and disease progression and to explore the potential therapeutic application of CRISPR-modified iPSC microglial transplantation
