“Expanding the Chemical Space of DNA-Encoded Libraries in Two and Three Dimensions”
Carol Mulrooney | GSK
This talk will focus on the design, physicochemical properties, and chemical space of DNA encoded libraries that are synthesized and screened at GSK and our success in finding confirmed binders and clinical candidates from these DELs. Using cheminformatics methods to evaluate the diversity and property distributions of our collections of small molecule ligands, we demonstrate that our current design strategy balances efficiency and drug-like properties while covering diverse chemical space.
