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Department Seminar: “Chemistry to discover and decode acetylation regulatory mechanisms” featuring Jordan Meier
February 22, 2018 @ 4:00 pm - 5:00 pm
“Chemistry to discover and decode acetylation regulatory mechanisms”
Chemical Biology Laboratory
Head, Epigenetics and Metabolism
National Cancer Institute, Center for Cancer Research
Thursday, February 22, 2018
4:00 PM – 5:00 PM
McGaugh Hall 1246
A paradox of modern acetylation biology is that the while number of sites of acetylation has climbed rapidly, the number of enzymes thought to catalyze this process has stayed relatively constant. Here we describe the utility of chemical proteomic methods to discover and characterize novel mechanisms of acetylation in endogenous cellular contexts. Our studies highlight an expanded landscape of regulatory acetylation in gene expression control, as well as new strategies to investigate the metabolic regulation and small molecule inhibition of acetyltransferases in cells.
About Jordan Meier
Dr. Meier received his undergraduate degree in chemistry from Creighton University in 2004, getting introduced to research as an National Science Foundation REU student. Following graduation he moved to the University of California-San Diego, performing graduate research in natural products biochemistry and proteomics under the mentorship of Professor Michael D. Burkart. After receiving his Ph.D. in chemistry in 2009, he moved to the California Institute of Technology. His research as an American Cancer Society postdoctoral fellow in the laboratory of Professor Peter B. Dervan focused on the development of high-throughput sequencing methods to analyze small molecule-DNA interactions. In 2013, Dr. Meier joined the NCI, where his research focuses on the development of synthetic probes to investigate metabolic and epigenetic signaling pathways in cancer.